42 Years - A Professional Law Corporation - Helping Asbestos Victims Since 1974

Posts by: Steven Kazan

International Mesothelioma Interest Group Young Investigator Award Recipient Licun Wu

Dr. Licun Wu

In celebration of the meeting of the International Mesothelioma Interest Group’s recent meeting in Boston, at iMig 2012, we at Kazan, McClain, Lyons, Greenwood and Harley funded this year’s Young Investigator Awards, as we have done at each meeting since 2008. This is the third in a series of entries discussing the promising work of one of the recipients.

Researchers from the University of Toronto are figuring out how to use the body’s own immune system to boost the efficacy of chemotherapy in the treatment of malignant mesothelioma. Dr. Licun Wu, one of the scientists heading this work, was kind enough to sit down with us and discuss this exciting approach to medicine.

Activating the body’s defenses
Several medical experts are exploring ways to use the body’s immune system to kill malignant cells, according to the American Cancer Society. These approaches, collectively known as immunotherapy, may act directly on the cancer or support the actions of healthy cells.

In their laboratory, Wu and his team are focusing specifically on the behavior of the immune system between cycles of chemotherapy.

“Cancer cells tend to repopulate during the breaks between chemotherapy treatments. Evidence has shown that the rate of repopulation of surviving cancer cells accelerates over time, so better approaches to stop this process need to be developed,” said Wu.

The research team’s experiments revealed that blocking the actions of CTLA-4, a protein that acts as a brake on certain immune responses, helps prevent mesothelioma cells from repopulating during breaks in chemotherapy. Reining in this protein may allow a type of immune cell known as natural killer T cells to flourish and fight the disease.

This study potentially lays the groundwork for clinical trials that use CTLA-4 blocking medications. We at Kazan Law are happy to support this research, as we know that diversifying the types of treatments available to mesothelioma patients will do them a world of good by giving them more than one way to fight this disease.

Related posts:

International Mesothelioma Interest Group 2012 Young Investigator Award Recipient Karin Schelch

International Mesothelioma Group 2012 Young Investigator Award Recipient Yuen Yee Cheng

Final Asbestos Mine in Quebec Quits Plans to Reopen

An asbestos mining company in Quebec recently announced that it has abandoned plans to revive one of the last asbestos mines in the province.

The Lac d’Amiante du Canada mine (LAC) at Thetford Mines, Quebec, was closed down after a landslide caused mining operations there to be halted. Following the closure, the Committee to Re-launch the LAC Mine was formed to try to resume operations, according to RightOnCanada.ca.

About two months after the closure the company that operated the LAC mine, LAB Chrysotile Inc., declared bankruptcy. And now Simon Dupéré, the company’s president, has announced that plans to reopen the mine have been suspended indefinitely.

According to the news source the reason for this was because of recent decisions by the Canadian and Quebec governments that signified opposition to the resumption of asbestos mining in the country.

Jeffrey Mine has loan canceled

Earlier this month the president of the Jeffrey Mine in the town of Asbestos, Quebec, Bernard Coulombe, said that the $58 million loan from the government that would have revived the closed mine had been cancelled, reports the Montreal Gazette.

The prospect of the loan has been a major source of controversy in recent years, with health advocates decrying the fact that Canada was exporting asbestos around the world while restricting its use domestically.

Dangers of exporting asbestos

While the use of asbestos is highly dangerous everywhere, it can be especially harmful when used in developing nations – such as the ones that were buying Canadian asbestos – because there are fewer regulations governing its use.

Any amount of asbestos exposure can have deadly consequences as the inhalation of the deadly mineral fibers has been proven for decades to cause a range of serious illnesses such as asbestosis, lung cancer and malignant mesothelioma, a rare and deadly cancer that attacks the thin membrane that lines the body’s chest, lungs and abdomen.

These diseases claim the lives of 107,000 people each year around the world, according to World Health Organization figures.

New Quebec government deserves praise

Dupéré said that the Parti Québécois’ newly formed government made it clear that the asbestos industry would no longer be supported, according to RightOnCanada.ca. According to Dupéré, it would now be virtually impossible to attract the foreign investors needed to reopen the LAC mine.

International Mesothelioma Group 2012 Young Investigator Award Recipient Yuen Yee Cheng


In celebration of the meeting of the International Mesothelioma Interest Group, or iMig 2012, we at Kazan, McClain, Satterley, Lyons, Greenwood & Oberman funded this year’s Young Investigator Awards, as we have done at each meeting since 2008. This is the second in a series discussing the promising work of one of the recipients.

Australia was once home to one of the world’s most thriving asbestos industries, which left behind a dubious legacy of health problems. Fortunately, a generation of scientists decided to respond to this legacy by establishing the Asbestos Diseases Research Institute (ADRI), located at the University of Sydney.

At iMig 2012, we had the pleasure of meeting Dr. Yuen Yee Cheng, who was happy to discuss her work on epigenetics and the suppression of malignant pleural mesothelioma (MPM) tumors.

Silencing the disease

Cancer is a complex condition that is influenced by a wide number of variables, including lifestyle choices, genetics and pollution. When it comes to MPM, the main driving factor in the development of the disease is a history of asbestos exposure, which can cause pathological changes in the mesothelial cells of the lungs.

Healthy mesothelial cells contain an active gene known as ZIC1, which plays an important role in suppressing behavior that could lead to the development of tumors. Past studies have shown in gastric and colorectal cancer cells, ZIC1 was silenced. In order to determine if the same was true in MPM, Cheng and her team conducted a study that looked at cell and tumor samples.

Results showed that the activity of ZIC1 was hampered in 16 of 24 MPM tumor samples, leading to the production of microRNAs (a type of chemical messenger within a cell) that are associated with disease activity. However, stimulating the expression of ZIC1 reduced the levels of these abnormal microRNAs, which interfered with the tumor growth.

This is an important observation because it may inspire researchers to take a new approach toward treating MPM. This disease is not going away any time soon. In fact, the Environmental Working Group predicts that we may even see more cases of it popping up in years to come.

Thankfully, scientists at places like ADRI are up to the task of solving these problems – and we are happy to support their work.

“My ultimate aim is to find a cure for mesothelioma,” Cheng told us. “I would like to thank the ADRI and the Asbestos Diseases Foundation of Australia for their support. And I would sincerely like to thank the professional law corporation Kazan, McClain, Satterley, Lyons, Greenwood & Oberman for supporting the Young Investigator Award.”

Related posts:

International Mesothelioma Interest Group Young Investigator Award Recipient Licun Wu

International Mesothelioma Interest Group 2012 Young Investigator Award Recipient Karin Schelch

 

Post-Earthquake Demolition in Japan Poses Asbestos Exposure Risk

building destroyed by earthquakeThe Great East Japan Earthquake that struck the Sanriku Coast and the surrounding areas in March 2011 killed nearly 16,000 individuals and endangered the nuclear power plant located in the Fukushima Prefecture, according to the Ministry of Foreign Affairs of Japan. Subsequently, various buildings affected by the earthquake required demolition.

Those of us at Kazan, McClain, Lyons, Greenwood and Harley shared the collective concerns of everyone around the world who heard about the devastation.

Recently, a government study indicated that improper safety measures at various demolition sites increased the local level of asbestos exposure, as reported by the Yomiuri Shimbun, a Japanese newspaper.

Exceeding the limits

Another earthquake in 1995 also led to the demolition of several buildings. Eventually, three workers involved in these projects developed tumors that were associated with exposure to asbestos, leading to a government study on 36 building sites. Results showed that the concentration of asbestos at three locations exceeded 10 parts per liter of air, which is the safety limit put forth by the World Health Organization (WHO), according to the news source.

Following the 2011 earthquake, 114 sites located throughout Fukushima and other prefectures were designated for demolition, leading to the new study to measure the level of contamination around the sites.

Results showed that air concentrations of asbestos surpassed safety limits at 14 sites, ranging from 10.6 to 783.5 parts per liter of air. The greatest level was found in a Sendai hotel. City officials found that demolition crews did not employ the necessary asbestos exposure precautions, such as covering the walls with plastic sheets.

Government agencies speculate that the large amount of demolition work required after the earthquake overwhelmed crews and led to neglect of safety measures.

“Following the new findings, the Environment Ministry plans to revise the Air Pollution Control Law, which stipulates measures to prevent asbestos-related health damage, to bolster the ministry’s authority to conduct on-the-spot inspections,” the news source said.

Reduction efforts in Japan and beyond

Asbestos was widely used in Japan throughout the 1960s, particularly in the construction industry. However, in recognition of the health risks posed by the hazardous mineral, the government implemented an ordinance in 2006 that banned the use of materials that were more than 0.1 percent asbestos by weight.

More than 107,000 individuals around the world die from asbestos-related illnesses, such as malignant mesothelioma, according to the WHO. This led the agency to support and design several international efforts to curb the use of asbestos

International Mesothelioma Interest Group 2012 Young Investigator Award Recipient Karin Schelch

In celebration of the meeting of the International Mesothelioma Interest Group, or iMig 2012, we at Kazan, McClain, Satterley & Greenwood funded this year’s Young Investigator Awards, as we have done at each meeting since 2008. This is the first in a series discussing the promising work of one of the recipients.

If there is one thing that defines a researcher, it is a never-ending desire to improve upon science’s current body of knowledge. When it comes to the search for a cure for malignant pleural mesothelioma (MPM), this drive usually means good news for patients.

At iMig 2012, we met Karin Schelch, a PhD candidate in molecular biology, who was kind enough to talk to us on video about her team’s research on fibroblast growth factors (FGF) and fibroblast growth factor receptors (FGFR). Both sets of these proteins may serve as targets for MPM treatments.

Defining the roles of the proteins in MPM

According to Schelch, FGF is important for the growth and survival of cells. However, it can also drive the development of several types of malignancies.

Despite this knowledge, the specific role of FGF in MPM had not always been entirely clear. This makes FGF and FGFR important topics for research because a better understanding of their biology can, in turn, lead to a better understanding of how to tackle mesothelioma.

In the laboratory, Schelch and her team conducted several experiments that included MPM cell models, normal mesothelial cells and human tissue samples. Specifically, the researchers were looking at what cells made what proteins.

Ultimately, they found that MPM cells and tumorous tissues have three abnormally active genes: FGFR1, FGF2 and FGF18. Through different experiments, the scientists discovered that stimulating the cells with FGF2 made them more invasive, and that blocking the actions of FGFR1 made the spread and survival of cancer cells more difficult.

“Our data show that blocking the fibroblast growth factors could be a new and more efficient option for mesothelioma treatment,” Schelch told us.

Furthermore, one experiment revealed that diseased cells that are resistant to cisplatin, a standard medication for MPM, are also more sensitive to FGFR1 inhibition. This is good news, considering that Schelch and her team theorize that blockage of FGFR1 could work well in combination with chemotherapy and radiation treatments.

These results were so exciting that the team presented this study at iMig 2012. And on behalf of MPM patients everywhere, we are happy to support work like this.

Related posts:

International Mesothelioma Interest Group Young Investigator Award Recipient Licun Wu

International Mesothelioma Group 2012 Young Investigator Award Recipient Yuen Yee Cheng

Caregivers of Mesothelioma Patients can Benefit from Support Systems

caregiver with elderly manAt Kazan, McClain, Lyons, Greenwood and Harley, we not only care about clients who are battling malignant mesothelioma and other asbestos-related diseases, but we are engaged with their loved ones as well. As this illness advances, patients need more extensive care in order to live as comfortably as possible. In some cases, a relative or friend may take on the role of caregiver.

We recognize that this is a noble and loving gesture, considering that most patients with advanced illnesses prefer to live at home rather than a long-term care institution. In this post, we offer some tips that hopefully can be informative for those who decide to become caregivers for our clients who have asbestos-related diseases.

A wide range of tasks

As a caregiver, you are considered part of a patient’s medical team. According to the American Cancer Society (ACS), your tasks may include keeping track of appointments, handling insurance issues, making sure the patient is getting enough food and rest, following medication instructions and helping with everyday functions such as bathing and dressing.

The ACS has several guidelines to ensure that you provide the best care you can:

  • Keep the patient involved in his or her treatment plan.
  • Allow the patient to make their own decisions, but provide guidance if their judgments are poor.
  • Encourage the individual to do as much as they can to care for themselves.
  • Be mindful of your own needs, including rest, exercise, healthy eating and medical care.
  • If you are feeling overwhelmed, turn to the rest of the medical team for guidance.
  • Don’t be afraid to ask for help from others so that you can take time for yourself. Make a list of tasks you need the most help with, and check with loved ones to see if they are able to assist with anything specific.

These tips will become increasingly important as more individuals are diagnosed with asbestos-related diseases. According to the Environmental Working Group, the incidence of these illnesses may not peak for another decade or more.

Good ways and bad ways to tackle stress

It is normal to feel frustrated, fatigued or otherwise burned out from having to take care of a sick loved one. All people need to figure out the best way for them to deal with stress.

According to the ACS, healthy coping mechanisms include eating healthy food, exercising five times a week, engaging with a religious community, turning to internet support groups, practicing relaxation techniques such as yoga and staying in contact with supportive friends and family.

In contrast, tobacco use, sleep medication, alcohol consumption or bringing work home can aggravate stress.

Kazan Law Leads Efforts to Pass AB 1875

On September 17, 2012, California Governor Jerry Brown signed a bill that Kazan Law was instrumental in advocating. A significant triumph for organizations that seek justice for consumers and workers, AB 1875 places limits on how long a deposition may take.

Deposition abuse – extending depositions of victims for days on end – has been a problem not only for those suffering from asbestos-related diseases, but also for others who may be enduring similar situations. AB 1875 now limits victims’ depositions of ill and dying victims, including those dying from asbestos, to two days of seven hours each, for a total of fourteen hours. Exceptions can be made if a judge decides that more time is absolutely necessary.

Kazan Law has witnessed many appalling instances of deposition abuse in our nearly 40 years fighting for asbestos victims. Our clients and those represented by other lawyers have been made to endure marathon depositions from defense attorneys that sadly ended with tragic consequences. Consider these cases as examples of victims who could have been protected with AB 1875:

John Tommaney’s doctors told him that the mesothelioma would not respond to radiation or chemotherapy and that hospice care should be arranged. In our direct-examination deposition, Mr. Tommaney shared all of his pertinent knowledge about his life and imminent death in testimony lasting just four hours. The defense attorneys’ cross-examination went on to prolong questioning for more than 26 hours over a span of 22 days. On the 23rd day, his attorney informed the defendants, “Mr. Tommaney is unavailable for deposition today as he died last night.”

Mesothelioma victim John Johnson was aggressively deposed for 25 hours over the course of 41 days while his health drastically declined. Less than one hour after his last deposition session, Mr. Johnson was rushed to the hospital, where he died. In his medical records, the diagnosis is listed as “sudden cardiac arrest while giving a courtroom deposition.”

Bob Thacker did not live long enough to see his day in court. Mr. Thacker passed away after 22 days of deposition, most of which was repetitive and pointless. Unfortunately, Mr. Thacker’s survivors did not have the same legal rights after he died, and his death prevented the responsible party from being held fully accountable.

California Assemblyman Mike Gatto (D – Burbank) is the author of AB 1875, which was introduced on February 22, 2012, and passed the full California Legislature. The Consumer Attorneys of California was the official sponsor of the legislation.

In our efforts to pass AB 1875, Kazan Law staff met with members of the California Legislature in both the Assembly and Senate and urged their support of the bill. Kazan clients wrote letters to their State Senators also urging their support. All Democratic State Senate Members, except Juan Vargas, voted for the bill. All Republican State Senate Members, except for two abstentions, voted against protecting asbestos victims.

UICC Seeks Global Ban of Asbestos

The Union for International Control of Cancer (UICC) took a major step recently when it called for a complete ban on the mining, use and exportation of all forms of asbestos, Right On Canada reported.

According to the news source, the UICC, which includes more than 700 member organizations throughout 155 different countries, pointed specifically to countries that mine and export the carcinogenic substance. The organization sought to halt these mining and exportation practices, while offering economic assistance during the transition period for mining communities.

One community that immediately comes to mind is that of the appropriately named Asbestos, Quebec. With Canada well-known for its exportation of asbestos to developing countries, the town of Asbestos is a major factor, as it hosts the Jeffrey Mine. The mine recently received a boost in the form of a $58 million loan from the government. This, despite a number of calls for Canada to bring its exportation policies more in line with its asbestos restrictions at home.

UICC statement points to scientific evidence

In its Position Statement calling for the ban of asbestos and the halting of such exports, the UICC noted that there has been a known link between asbestos and lung disease since the early part of the 18th century. Since the mid-1960s, it has been known that exposure to asbestos can lead to the development of lung cancer, asbestosis and malignant mesothelioma, a rare form of cancer.

Such evidence is a major factor in the decisions of many countries to adopt bans on asbestos, particularly when the true toll of asbestos-related diseases is taken into account. According to the UICC’s statement, more than 92,000 mesothelioma deaths were reported in 83 different countries between 1994 and 2008.

Further, according to the World Health Organization, approximately 107,000 people around the world each year succumb to asbestos-related diseases like asbestosis, lung cancer and mesothelioma.

Children May be Fragile Following Mesothelioma Diagnosis of a Relative

older woman holding girlA diagnosis of cancer, including malignant mesothelioma, can affect all aspects of an individual’s life – work, leisure time activity, plans for the future, spirituality and relationships. Children in particular can be sensitive to the news about a loved one’s diagnosis because they may not always be mature enough to deal with their feelings on their own. In these cases, they may need help from their parents, counselors or other trusted adults.

At Kazan, McClain, Lyons, Greenwood and Harley, we want to make sure that every member of the family – including the youngest and most tender – gets the support that he or she needs.

Breaking the news

The bottom line in helping children understand what is happening is to be truthful with them. According to the American Cancer Society, the most basic information that all kids need include the name of the disease, the affected part of the body, how it will be treated and how their lives may change.

However, the level of details that you share with them depends on their age. Younger children may need to be reassured that they did not do anything to cause the mesothelioma, and that the condition is not contagious.

If they wonder whether their relative will die from mesothelioma, it is important to remember that although the truth is necessary, that does not mean everything needs to be shared all at once. In this case, it may be better to focus on the present, and save potentially devastating news for when a prognosis is definite.

These discussions are best held in an environment free of potential distractions or interruptions. It will be helpful to plan what to say ahead of time, and emphasize that the lines of communication will always be open for questions or concerns.

All children are unique, so each youngster may react to the news in a different way. Even though they may not always be able to articulate their feelings, they will always show them in some way. Signs that a child may need professional help include chronic sadness, persistent irritability, changing grades, differences in appetite, insomnia and difficulty concentrating.

Maintaining routines

According to the Dana-Farber Cancer Institute, routine can create a sense of security for children. To that end, mealtimes, bedtimes and other scheduled activities should be maintained. Any changes, such as a visit to the hospital, need to be discussed ahead of time. Furthermore, it is important to maintain discipline and behavioral limits.

Some, but not all, children may like to help out around the house with chores. However, parents need to remember to be realistic about these tasks, and to allow kids to have fun just being kids.

Mesothelioma Patients can Learn to Cope with ‘Chemo Brain’

comtemplative manIf you’ve been newly diagnosed with malignant mesothelioma, you already know that you’ll have to make some major adjustments. While there is no cure for this disease, there are different treatments that can make life as functional and comfortable as possible. Chemotherapy is one of the regimens most commonly used to help patients.

However, this treatment can cause side effects. Among them? Chemo brain.

Fog and forgetfulness while fighting disease

According to the National Cancer Institute, it’s not uncommon for patients who are fighting malignant diseases to experience confusion, depression or forgetfulness – all of which can be possible side effects of chemotherapy.

Medical experts have a hard time agreeing on how common chemo brain is among patients taking these medications. Scientists from the University of California, Los Angeles (UCLA) point out that estimates range from 25 to 82 percent.

But one thing is certain: Chemo brain is real.

In order to understand why cancer patients have these neurological symptoms, UCLA researchers conducted an experiment in which they imaged the brains of three groups of women: breast cancer patients who had chemotherapy, those treated with surgery and healthy women who never had breast cancer or chemotherapy.

The cortical images taken during this experiment showed that blood flow and metabolism were different in the brains of patients who had chemotherapy.

Later, when the test subjects were taking memory tests, brain scans showed that the chemotherapy patients’ brains had to work harder, compared to those of the healthy women.

There are ways to deal with chemo brain

At Kazan, McClain, Lyons, Greenwood and Harley, we’re committed to helping all of our clients who have mesothelioma cope with the changes in their lives as best as we can.

From the Mayo Clinic, we’ve learned about several ways that people with mesothelioma can deal with chemo brain:

  • If you have trouble concentrating, try eliminating noise and other distractions from your environment.
  • Before taking on a complex task, try to plan ahead, remember to eat right and get plenty of sleep – all these things will boost your focus.
  • Use tools, such as daily planners or calendars, to stay organized.
  • If you’re tackling a long and labor-intensive task, take plenty of breaks to let your mind rest
  • Keep your brain sharp with the help of crossword puzzles and other games.
  • Remember to exercise. Physical activity can help alleviate fatigue, stress and depression.
Get a Free Case Evaluation
The owner of this website has made a commitment to accessibility and inclusion, please report any problems that you encounter using the contact form on this website. This site uses the WP ADA Compliance Check plugin to enhance accessibility.